Ethyl 3-(N,N-dimethylamino)acrylate
[CAS 924-99-2]

Identification

• Classification: Organic raw materials >> Carboxylic compounds and derivatives >> Carboxylic esters and their derivatives
• Name: Ethyl 3-(N,N-dimethylamino)acrylate
• Synonyms: 3-(Dimethylamino)-2-propenoic acid ethyl ester
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• CAS Registry Number: 924-99-2 (1117-37-9)
• EC Number: 677-349-6
• SMILES: CCOC(=O)/C=C/N(C)C

Properties

• Solubility: Soluble (90 g/L) (25 °C), Calc.^*
• Density: 0.964±0.06 g/cm³ (20 °C 760 Torr), Calc.^*
• Boiling point: 185.9±23.0 °C 760 mmHg (Calc.)^*
• Flash point: 68.9±13.5 °C (Calc.)^*
• Index of refraction: 1.452 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H317
• Safety Statements: P261-P272-P280-P302+P352-P321-P333+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin sensitization	Skin Sens.	1	H317
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

chemBlink Chemical Story

Ethyl 3-(N,N-dimethylamino)acrylate is an enamine ester in which an electron-rich dimethylamino group is conjugated through a carbon-carbon double bond with an electron-withdrawing ethyl ester. This push-pull arrangement makes the molecule useful for constructing heterocycles and functionalized unsaturated compounds. The dimethylamino group can act as an activating substituent and, in suitable reactions, as a leaving group, while the ester remains available for hydrolysis, amidation, reduction, and other transformations. Enamino esters are valuable because their carbon atoms are electronically differentiated, allowing regioselective bond formation with nucleophiles or electrophiles. Public exact-CAS information is principally synthetic, so this substance is best described as an organic and medicinal-chemistry intermediate rather than an active drug.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

Practical behavior emerges from the complete molecular and material system. Structure, physical form, reaction conditions, manufacturing route, and surrounding environment can all affect performance. Connecting these details to a documented synthetic, industrial, analytical, or biological role is what turns a registry entry into a meaningful chemical story.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

References:
1. Specialist chemical catalogs. CAS 924-99-2.
2. Reviews of enamino esters in heterocyclic synthesis.

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